Recent research has suggested that the expression of Th17 cells, Th17 cytokine, and IL-17 represented a high level in laryngeal carcinoma.[18–19] It has been shown that the expression of IL-22 was significantly up-regulated in the serum of patients with laryngeal carcinoma.[19] The purpose of the present study was to elucidate the expression of IL-22, IL-22R, and correlative factors in LSCC and to explore the relationship of these factors in clinicopathological characteristics and prognosis. The gene discussed is IL22; the disease is laryngeal carcinoma.