The STAT3 phosphorylation induced by IL-22 was observed in human colonic cancer, hepatocellular carcinoma, lung cancer, and oral squamous cell carcinoma.[5,9] In the immunohistochemical experiment, the expression of STAT3 was primarily observed in the nucleus of tumor cells and significantly up-regulated in LSCC. This evidence concerns the gene IL22 and oral cavity squamous cell carcinoma.