IL22 and neoplasm: Previous studies have shown that inflammation contributes to the proliferation, migration, and survival of cancer cells, which may lead to tumor invasion and metastasis.[3] Interleukin (IL)-22 is a member of cytokines of the IL-10 family.[4] The signaling of IL-22 receptor in epithelial cells promotes cell defense programs by partly regulating the proliferation and survival of cells.