But the expression of IL-22 and IL-22R1 had weak correlation with patient gender (P = .662, P > .99), age (P = .153, P = .565), tumor location (P = .374, P > .99), T stage (P = .204, P = .140), and pathologic differentiation (P = .061, P = .626). This evidence concerns the gene IL22RA1 and neoplasm.