Serum HCY levels gradually increase across the MT period to the postmenopausal period because of the extreme fluctuations in estrogen and FSH levels during the MT stage.[11] HCY has been confirmed to be a strong inflammation-inducing factor that can cause endothelial cell damage and is an independent risk factor for cardiovascular disease.[12,13] Increased levels of HCY predispose to endothelial injury, stimulate HDL oxidation through an increase in the activity of methionine synthetase, and affect the proliferation of endothelial smooth muscle cells. This evidence concerns the gene BRD2 and cardiovascular disorder.