AKT1 and Hirschsprung disease: Moreover, recent studies have suggested that lncRNAs may be candidates for targeted therapy aimed at alleviating or even curing diseases,[18,19] while other studies have reported the key role lncRNAs play in regulating miRNA expression in many diseases.[20,21] In fact, they act as a scaffold that coordinates specific regulatory functions[22] or compete for endogenous RNA.[23] In Hirschsprung's disease, lncRNAFAL1 was found to regulate AKT1 expression by competing with miR-637 as a ceRNA.[24]