In diabetic patients, the lack of insulin or defective utilization of insulin keeps glucose in the body at high levels, this long-term high blood sugar would damage many tissues of the body, and increase the risk of cardiovascular disease, kidney disease, and diabetic neuropathy in diabetic patients.[1] Traditional Chinese exercises therapy is the most common exercise method to assist in the treatment of type 2 diabetes mellitus, and it plays an important role in controlling blood sugar and blood lipids and preventing complications.[2,3]. This evidence concerns the gene INS and diabetic neuropathy.