The interactions that occur between viral surface proteins and host cell receptors are the basis for viral infectivity and transmissibility.[16] SARS-CoV-2 expresses the surface glycoprotein S1 (spike protein), which contains a receptor binding domain (RBD) that interacts with the angiotensin-converting enzyme 2 (ACE2), enabling the onset of infection.[17] Previous studies demonstrated that heparin and its analogues are able to bind to the SARS-CoV-2 spike protein and block SARS-CoV-2 infection using therapeutic relevant concentrations. This evidence concerns the gene ACE2 and infection.