Therefore, artificial assisted reproduction technology (such as intracytoplasmic sperm injection, ICSI) is usually of great help to male patients with PCD.[2] ICSI have allowed some of these individuals to become fathers using their own spermatozoa, using modified hypo-osmotic swelling test (HOST) to select immotile spermatozoa.[13] Here, we report a 23-year-old man diagnosed as PCD in a nonconsanguineous family having 2 novel mutant allele in CCDC40. The gene discussed is CCDC40; the disease is primary ciliary dyskinesia.