Although the common gene mutations associated with thyroid cancer such as KRAS, NRAS, HRAS, BRAF, PIK3CA, RET, and MMR-relating gene were not detected in the next-generation DNA sequencing, four point mutations were identified: DICER1: p. L1642fs, DICER1: p. E1813G, BCL6: p.R575C, and PMS1: p.P889S. This evidence concerns the gene PIK3CA and thyroid cancer.