CD5, CD23, CD10, and CD27 in hair cells are usually negative or weakly expressed, whereas CD11c, CD103, CD123, and CD25 are positive.[1] One case of HCL with atypical immunophenotype of CD103 (−) and CD23 (+) admitted to our department was recently reported to discuss the clinical characteristics, diagnosis, differential diagnosis, treatment, and prognosis of HCL, and to review the literature. This evidence concerns the gene FCER2 and hairy cell leukemia.