Second, acupuncture-rehabilitation therapy can improve the activity of superoxide orgotein dismutase (SOD) and downregulate the content of malefic dialdehyde (MDA) in peripheral blood of VCI patients with T2DM, and upregulate the expression of brain-derived neurotrophic factor (BDNF), so as to play the role of anti-oxidative stress and brain protection. This evidence concerns the gene SOD1 and type 2 diabetes mellitus.