GNRH1 and central precocious puberty: Precocious puberty refers to the presence of secondary sexual characteristics in boys <9 years of age and girls <8 years old.[1,2] Central precocious puberty (CPP) is triggered by the early activation of the hypothalamic-pituitary-gonadal (HPG) axis, resulting in inappropriate release of gonadotropin-releasing hormone (GnRH) and the onset of puberty.[3] The incidence of CPP has been estimated to be about 1:5000 to 1:10,000 people, with the female/male ratio being about 10:1.[4] In China, the incidence of CPP has increased in recent years.