MMP2 and abdominal aortic aneurysm: Dysregulation of MMP production and activity leads to extracellular matrix degradation and medial layer degeneration.[16] Examination of smooth muscle cells from abdominal aortic aneurysm shows an upregulated expression of MMP-9 and MMP-2.[17] Fluoroquinolones have been shown to affect the synthesis of collagen in the tendon cell and disorganization of the extracellular matrix in the cornea.