A report showed that inhibition of histone acetylation by curcumin reduces alcohol-induced fetal cardiac apoptosis,[32] and that histone deacetylases are target enzymes for cancer therapy,[33] and some anti-methylation agents have been used in tumors treatments.[34] We used gene engineering and exogenous inhibitors to alter epigenetic modifications and found that after these treatments, TNF-α overexpression in OA was suppressed by both. This evidence concerns the gene TNF and cancer.