Variables that showed a significant difference (P<0.05) were further entered into multivariate Cox regression analysis, which was conducted to evaluate the correlation between NT-proBNP and long-term mortality after adjusting for gender, atrial fibrillation, heart rate, MWT, NYHA III or IV, LVEF, BUN, and BMI. The gene discussed is NPPB; the disease is atrial fibrillation.