In mCRPC, a direct negative regulation of AR signalling (including its downstream targets such as EHF) and FOXA1 by ONECUT2 has been reported by Rotinen et al., together with increased expression of PEG10, a putative target gene of ONECUT2 being in primary PCa repressed by AR and REST [172]. This evidence concerns the gene PEG10 and posterior cortical atrophy.