Similarly, remodelling of epigenetic and transcriptional landscapes mediated by transcriptional repressor Enhancer of Zeste homolog 2 (EZH2) [122,158,159], pro-neuronal splicing regulator SRRM4 [160,161], or transposable element Paternally expressed 10 (PEG10) [162,163] has been reported to promote neuroendocrine differentiation of PCa as well. Here, PEG10 is linked to posterior cortical atrophy.