We further demonstrated that glycodeoxycholic acid (GDCA) and tauroursodeoxycholic acid (TUDCA) were decreased due to the deconjugation of BSH in PCOS patients and that supplementation with these bile acids can improve the PCOS phenotype by activating TGR5 and further enhancing IL-22 secretion by intestinal Group 3 innate lymphoid cells (ILC3s) [58]. Here, IL22 is linked to polycystic ovary syndrome.