Finally, in order to identify conserved biological themes related to AK4 transcript expression in LUAD, a comprehensive LUAD tumor AK4 co-expression network was constructed of stage-specific tumor AK4 gene signatures, encompassing both early (stage 1/2) and late (stage 3/4) developmental milestones of LUAD tumor growth and metastasis. This evidence concerns the gene AK4 and neoplasm.