Given the combined roles of ANGPT1 and Tie2 in negatively regulating angiogenesis and vascular permeability, suppressed expression of these transcripts, in the context of upregulated EGF and TIMP-1 transcripts, predicts pro-angiogenic signaling along the HIF-1 signaling axis that runs throughout the early and late stages of LUAD tumor development. The gene discussed is HIF1A; the disease is neoplasm.