C3 and infection: Joint pathway and interaction analysis of differentially expressed proteins and metabolites revealed crosstalk among potential candidates such as valproic acid, leucic acid, 4-hydroxy-2-oxoglutaric acid, F2, glycerol, SERPING1, KNG1, FN1, BHB, CP, and C3, which could be responsible for restoring associated complication of NEB such as infertility, or infection such as mastitis.