When the manufacturer’s AUC < 71 cut-off value was used in comparison, the tPA lysis time (tPA LT) tended to increase among aspirin ‘responder’ COVID-19 patients (p = 0.06) compared to ‘non-responders’, and eight of these patients showed features of the ‘fibrinolysis shut-down’ phenomenon. The gene discussed is PLAT; the disease is COVID-19.