NOS2 and colitis: NO is produced from L-arginine by three main isoforms of nitric oxide synthase (NOS): epithelial NOS (eNOS), related to vasodilation and vascular regulation; neuronal NOS (nNOS), linked to various intracellular signaling pathways; and inducible NOS (iNOS), which has been reported to have beneficial microbicidal, antiviral, antiparasitic and antitumoral actions, but has also been implicated in the pathophysiology of colitis [33].