This, in turn, promotes the development of atherosclerosis as shown in the ApoE−/− and Ldlr−/− mouse models of this disease for several miRNAs, including miR-10b, miR-19b, miR-20a/b, miR-92a, miR-144, miR-145, miR-148, miR-188-3p, and miR-302a. The gene discussed is APOE; the disease is atherosclerosis.