For example, the inventors of the patent EP3054017A1 revealed that in the level of circRNAs detected by them, U1 (DENN domain containing 4C gene, DENND4C), U2 (PDS5 cohesin associated factor A gene, PDS5A), and U4 (zinc finger protein 292 gene, ZNF292) are increased in the plasma of patients with CAD, and the levels of U1 and U4 in the plasma of patients with acute myocardial infarction. The gene discussed is PDS5A; the disease is coronary artery disorder.