Intriguingly, its protective roles in other amyloidal neurodegenerative diseases are emerging, not only as an antioxidant but also as a receptor for oligomers of the β-amyloid peptide and tau playing a major role in the pathogenesis of Alzheimer’s disease (AD) or binding some forms of α-synuclein, which are involved in the Lewy bodies of Parkinson’s diseases [25]. Here, MAPT is linked to Alzheimer disease.