Wan et al. [54], for example, used molecular dynamics simulation to elucidate the mechanisms by which norepinephrine destabilizes tau protofilaments, and Fan et al. [55] used the same technology to demonstrate a mechanism by which wgx-50 (a natural compound of potential use as an AD-modifying drug) destabilizes Aβ protofibrils. The gene discussed is MAPT; the disease is Alzheimer disease.