IL6 and periodontitis: Diabetes contributes to periodontitis through multiple mechanisms, one of which is altering the oral microbiota to a more pathogenic composition with increased levels of bacterial species associated with periodontitis or poor periodontal healing in diabetic animals, and this ‘diabetic’ microbiota enhanced IL-6 production, osteoclasts differentiation, periodontal bone loss and inflammation when transferred to normoglycemic mice [37], and such microbiological changes can be seen even in both clinically healthy and resolved periodontal sites in T2DM patients [38].