High glucose (HG) was shown to induce Toll like receptor 2 (TLR-2), NF-ĸB pathway and IL-1β in human gingival fibroblasts [41] and RAGEs were upregulated on mRNA level in inflamed gingival tissues of T2DM periodontitis patients compared to their non diabetic periodontitis patients [42]. The gene discussed is IL1B; the disease is periodontitis.