Higher sPD-1 levels are also found in non-small cell lung carcinoma (NSCLC), diffuse large B-cell lymphoma (DLBCL), chronic lymphocytic leukemia (CLL), nasopharyngeal carcinoma (NPC), HCC, pancreatic adenocarcinoma, and advanced rectal cancer [74]. This evidence concerns the gene HOXD13 and hepatocellular carcinoma.