Additionally, we analyzed the Ls-TRPML protein by InterPro online website and found that Ls-TRPML is one canonical member of Mucolipin (TRPML) family, contains one transmembrane region (304–326 aa) and a Polycystic kidney diseases (PKD) channel domain (335–528 aa) (Figure S1D), indicating that Ls-TRPML is one member of TRPML and the functional modules are similar to the TRPML of flies and worms. Here, LIAS is linked to polycystic kidney disease.