Compared with the sequence similarities of Delta and Epsilon subfamilies of GSTs in BPH and their orthologous genes in S. furcifera, we found they share 89.40% nucleotide sequence similarity between NlGST1-1 and SfGSTD2, 89.55% similarity between NlGSTD2 and SfGSTD2, and 81.28% similarity between NlGSTE1 and SfGSTE1 (Figure S3). Here, HPGDS is linked to benign prostatic hyperplasia.