NTRK2 and Mental deterioration: Importantly, BDNF signaling, through its high-affinity receptor, tropomyosin receptor kinase B-full length (TrkB-FL), has been shown to enhance hippocampal-related plasticity mechanisms such as long-term potentiation (LTP), a crucial mechanism for learning and memory processes, and adult neurogenesis [14,15], while impaired signaling has been associated with cognitive decline in old age [16].