Accumulation of DeltaFosB in the basolateral amygdala was observed as a result of peripheral nerve injury in rats and associated with the emotional and affective component of pain [86], whereas chronic voluntary consumption of large quantities of ethanol induces FosB/DeltaFosB expression selectively in the DLS but not the DMS of rats, an effect mediated by endogenous opioids [87]. The gene discussed is FOSB; the disease is peripheral nerve injury.