CD274 and renal cell carcinoma: In first-line treatment of advanced or metastatic RCC, combinations of the checkpoint inhibitors (CPI) ipilimumab (anti–CTLA-4) and nivolumab (anti–PD-1), and anti–PD-L1 or anti–PD-1 in combination with anti-angiogenic agents, improved outcomes compared with the anti-angiogenic agent sunitinib in randomized phase III trials [6,7,10,11,12].