Histological features, such as tumour budding, perineural invasion, apical lymph node positivity, lymph node yield, lymph node ratio, and molecular features such as microsatellite instability (MSI), Kirsten rat sarcoma virus (KRAS), v-RAF murine sarcoma viral oncogene homolog B (BRAF), and caudal type homeobox 2 transcription factor (CDX2) have been used to guide prognostication and optimise adjuvant treatment, but there is no consensus on their role. The gene discussed is BRAF; the disease is neoplasm.