CD8A and colorectal carcinoma: CD3 and CD8 density has been reported as an independent prognostic factor with Eriksen et al. demonstrating that higher CD3 and CD8 counts were associated with improved RFS (HR = 1.39, p = 0.026 and HR = 1.39, p = 0.32 respectively) and OS (HR = 1.53, p = 0.004 and HR = 1.59, p = 0.003 respectively) in stage II CRC patients (n = 573) [207].