Table 1 shows the gross manifestations of different spleen neoplasms, splitting them into those presenting with diffuse miliary white nodules, large mass-like nodules, or a homogenous beefy red cut surface. SMZL is the only CD5-CD10-LPD that presents with diffuse miliary white nodules. SLL/CLL, FL, and MCL can present similarly, but they are usually CD5+ or CD10+ and are usually secondary lymphomas to the spleen. HCL and HCL-v do not show diffuse miliary nodules and instead present with a diffuse beefy red enlarged spleen without miliary nodules [5]. The gene discussed is CD5; the disease is spleen neoplasm.