CD274 and adenocarcinoma: In a Spanish multicenter study aimed at assessing PD-L1 expression in different tumor variants using CPS and SP142 assays, tumors with squamous cell or sarcomatoid differentiation and adenocarcinomas showed a high PD-L1 expression (accounting for 50% in some cases), whereas PD-L1 expression was almost absent in micropapillary, nested, plasmacytoid, clear cells and neuroendocrine variants (Figure 1).