Despite the fact that the trial was not able to detect outcome differences in non-ALCL PTCL, BV-CHP is now generally preferred to CHOP in these patients and is included in NCCN guidelines (category 2A), based on a toxicity profile that is overall comparable to CHOP (with the exception of sensory neuropathy) and the hope that the targeting of CD30 will produce additional clinical benefit [8]. Here, TNFRSF8 is linked to mature T-cell and NK-cell non-Hodgkin lymphoma.