The CCN family includes CCN1/CYR61 (cystein-rich 61], CCN2/CTGF (connective tissue growth factor), CCN3/NOV (nephroblastoma overexpressed), and also CCN4/WISP-1, CCN5/WISP-2, CCN6/WISP-3 (Wnt-inducible secreted proteins) [10,20]. The gene discussed is CCN4; the disease is Nephroblastoma.