While testing for beta-thalassemia is not part of the United States (U.S.)core Recommended Uniform Screening Panel (RUSP) (https://www.hrsa.gov/advisory-committees/heritable-disorders/rusp/index.html, (accessed on 30 November 2021)) for the 53 state and territorial newborn screening (NBS) programs, the methodologies used for the detection of sickle cell disease, which is a core RUSP condition that is performed by all programs, are also capable of detecting a significantly diminished ratio of Hb A to fetal Hb (Hb F). The gene discussed is GSTM1; the disease is thalassemia.