DLL4 and neoplasm: For instance, inhibition of VEGF in murine neoplasms promoted the decrease of DLL4 expression, inducing non-productive vessels formation within TME, since DLL4 is required for vascular organization; therefore, concomitantly, the blockade of dual VEGF and DLL4 can bring hope to have more potent effects in tumors than the solitary obstruction of either factor [95,119,120].