On the other hand, Q209 and R183 mutations in either GNAQ or GNA11 are rare in melanocytic neoplasms arising in the epithelium, which are more likely to carry mutations in the MAPK pathway components, BRAF, NRAS, and NF1 (Van Raamsdonk et al., 2010; Fecher et al., 2008; Nissan et al., 2014). This evidence concerns the gene GNA11 and melanocytic neoplasm.