FMRP, the RNA-binding protein whose activity is lost in Fragile X syndrome, represses translation (Bassell and Warren, 2008; Costa-Mattioli et al., 2009; Darnell et al., 2011; Laggerbauer et al., 2001) and is thought to be a key regulator of activity-dependent local translation in neurons (Banerjee et al., 2018; Bear et al., 2004; Huber et al., 2002; Lee et al., 2011). Here, FMR1 is linked to fragile X syndrome.