FMRP target genes overlap significantly with autism susceptibility genes and include genes involved in both synaptic function and transcriptional control in the nucleus (Darnell, 2020; Darnell et al., 2011; Iossifov et al., 2012; Sawicka et al., 2019), and loss of FMRP increases translation of chromatin modifiers such as BRD4 (Korb et al., 2017) and SETD2 (Shah et al., 2020). Here, FMR1 is linked to autism.