An avalanche of evidence has shown that TOP2A is overexpressed in various cancers, including HCC, malignant peripheral nerve sheath tumor, hepatoblastoma, breast cancer (BC), esophageal cancer, gastroesophageal cancer, pancreatic cancer, colorectal cancer (CRC), and prostate cancer (PCa) [6–9]. The gene discussed is TOP2A; the disease is Familial prostate cancer.