AR and posterior cortical atrophy: The AR antagonist bicalutamide also induced SGs similar to enzalutamide but interestingly, other therapeutics approved in advanced PCA, including the microtubule inhibitor docetaxel and the PARP inhibitor olaparib, did not induce SG formation when combined with a low dose of arsenite and used at concentrations that reduced cell survival (Supplementary Figure S3A and B).