Previously, we discovered that the highly conserved RNA-binding protein (RBP), YB-1, directly binds to the 5′-UTR of SG nucleator G3BP1 for translational activation, facilitating SG formation in many cancer types under stress; moreover, inactivation of YB-1 or G3BP1 reduced invasive and metastatic capacity (31). Here, YBX1 is linked to cancer.