Furthermore, it is possible to induce ALS‐like symptoms (i.e., progressive motor weakness and muscle atrophy with fasciculation and regional cytoplasmic mislocalization of TDP‐43) for instance by injection of AAV expressing TDP‐43 into cynomolgus monkeys (Uchida et al., 2012). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.