After it is fully phosphorylated, Akt maintains its catalytic conformation, is separated from PIP3 and transported to the cytoplasm, nucleus and mitochondria, where it regulates various target proteins and key nodes of downstream pathways by phosphorylating specific substrates, including mTORC1, Bad, GSK3, etc.55Thus, Akt can regulate the gene expression, protein synthesis, cell cycle, cytoskeleton and cell metabolism of cells, making the PI3K/Akt pathway an important participant in the occurrence and development of cancer.56 The gene discussed is PIK3CA; the disease is cancer.