However, in children, the aberrant Treg-dependent tolerogenic pathways have not been shown, and in pediatric CVID patients, the more severe disease pattern has been ascribed to the skewed Th1 polarization and excessive C–C chemokine receptors CCR5 (CD195) and CCR7 (CD197) expression [39]. The gene discussed is CCR5; the disease is common variable immunodeficiency.