TP53 and cancer: Many published papers have demonstrated that p53 is a multitasking protein [57], shielding the cells against cancer on many levels, including nucleotide excision repair [58–61], base excision repair [62, 63], mismatch repair, DNA double-strand break repair and recombination [64, 65], nonhomologous end joining [66, 67], homologous recombination [68, 69], and interactions with REcQ helicases [70, 71].