HOS (p53-expressing) and Saos-2 (p53-deficient) osteosarcoma cell proliferation was assessed by the BrdU test, for the two different AgNP sizes (7 and 60 nm), six different concentrations (c1 = 10 ppm, c2 = 5 ppm, c3 = 2.5 ppm, c4 = 1.25 ppm, c5 = 0.625 ppm, and c6 = 0.3125 ppm), and three time periods (24 h, 48 h, and 72 h). Here, TP53 is linked to osteosarcoma.