PPARγ activation inhibits hepatic fibrosis by inhibiting the TGF-β1/Smad pathway and significantly attenuates unilateral ureteral obstruction-induced renal interstitial fibrosis by reducing the expression of fibronectin, collagen IV, and TGF-β1 [13, 22, 23]. The gene discussed is FN1; the disease is Ureteral obstruction.