SEMA6B and reading: Spearman’s correlation analysis illustrated that SEMA6B was strongly related to immune infiltration in COAD (Supplementary Figure S5A) and READ (Supplementary Figure S5B), especially for the five most significant infiltrators of immune cells, as follows: macrophages (r = 0.611 in COAD, r = 0.527 in READ), myeloid-derived suppressor cells (MDSCs) (r = 0.666 in COAD, r = 0.585 in READ), natural killer (NK) cells (r = 0.677 in COAD, r = 0.562 in READ), regulatory T cells (Tregs) (r = 0.619 in COAD, r = 0.586 in READ), and type-1 T helper (Th1) cells (r = 0.609 in COAD, r = 0.474 in READ).