The results revealed that SEMA6B was negatively correlated with tumor purity in COAD (r = −0.39, p = 2.86E-16) and READ (r = −0.39, p = 1.94E-06), whereas it was strongly positively correlated with infiltrating levels of CD4+ T cells (r = 0.504, p = 2.65E-27), macrophages (r = 0.465, p = 4.53E-23), neutrophils (r = 0.542, p = 5.37E-32), and dendritic cells (r = 0.545, p = 1.90E-32) in COAD (Figure 8B). Here, CD4 is linked to neoplasm.