Functionally, SEMA6B has been found to exert complex roles in the development and progression of tumors such as breast cancer (D'Apice and Costa 2013; Murad and Collet 2006), glioblastoma (Kigel and Rabinowicz 2011), gastric cancer (Ge and Li 2013), and testicular cancer (Ji and Wang 2020). Here, SEMA6B is linked to glioblastoma.