In CRC patients, miR-30b could mediate axon guidance and is significantly negatively correlated with SEMA6B (Coebergh van den Braak et al., 2018). Among different human cell lines, high levels of SEMA6B mRNA have been observed in MCF-7 breast adenocarcinoma cells, and these levels have been found to be downregulated by 9-cis-retinoic acid, an anti-proliferative and differentiation-promoting agent (Murad and Collet 2006). The gene discussed is SEMA6B; the disease is breast adenocarcinoma.