Our results showed that there were moderate-to-strong positive relationships between SEMA6B expression levels and infiltration levels of macrophages, MDSCs, NK cells, Tregs, and Th1 cells, as well as significantly positive correlations between infiltrating levels of CD4+ T cells, neutrophils, and dendric cells and SEMA6B expression in CRC. Here, SEMA6B is linked to colorectal carcinoma.