In contrast, GDM women with LGA infants had higher placental p-Akt, lower p-AMPKα, and higher p-mTOR levels than normal pregnant women; (2) primary cytotrophoblast cells subjected to OGD had lower p-Akt, higher p-AMPKα, and lower p-mTOR levels than cells cultured under standard conditions; (3) in contrast, increasing glucose concentrations led to higher levels of p-Akt and lower levels of p-AMPKα, and increased phosphorylation of mTOR than those observed under standard conditions. This evidence concerns the gene AKT1 and gestational diabetes.