The HS groups of all the five cancer types tested had a higher expression level of the 12 ferroptosis-related genes (GCLC, AKR1C3, AKR1C2, AKR1C1, SLC7A11, SLC3A2, G6PD, FTH1, SQSTM1, NQO1, ABCC1, and PGD). The gene discussed is AKR1C1; the disease is cancer.