The results suggested that elevated lymphocyte-derived CD4+ memory activated T cells (HR = 1.15), Tfh cells (HR = 1.12), and Treg cells (HR = 1.10) were significantly correlated with poor outcomes for ccRCC patients, while elevated myeloid-derived resting mast cells (HR = 0.89) predicted favorable prognosis for ccRCC patients. Here, CD4 is linked to nonpapillary renal cell carcinoma.