A recent study further showed that MeCP2 bound to METTL14 and enhanced the m6A level of KLF4, while m6A-modified KLF4 was supposed to be stabilized by IGF2BP2 to increase the expression of KLF4, thereby inhibiting the metastasis of CRC (Wang et al., 2021). This evidence concerns the gene KLF4 and colorectal carcinoma.