CDKN2A and cancer: For example, the INK4B-ARF-INK4A tumor suppressor gene locus is a well-known target of EZH2 and its inhibition affects cancer growth and embryonic development (Kheradmand Kia et al., 2009); E-cadherin gene is another critical target of EZH2, and its down-regulation is essential for EMT and metastasis (Luo et al., 2016).