HMGA1 and colorectal carcinoma: For example, miR-96 downregulated AMPKα2, thereby blocking its m6A modification and leading to increased FTO expression and subsequent upregulation of MYC expression (Yue et al., 2020); LNC00460 directly interacted with IGF2BP2 and DHX9 to bind to the 3′UTR of HMGA1 mRNA, thereby increasing the stability of HMGA1 mRNA (Hou et al., 2021); m6A modified circNSUN2 stabilized HMGA2 mRNA and ultimately promoted liver metastasis of CRC by forming a circNSUN2/IGF2BP2/HMGA2 RNA-protein ternary complex.