UCA1 isolates miR-135a, miR-143, miR-214, and miR-1271 to protect ANLN, BIRC5, IPO7, KIF2A, KIF23 and other actin and cytoskeleton related proteins from miRNA-induced degradation, and thus, regulates their expression and promotes the progression of CRC and other key biological processes (Barbagallo et al., 2018). The gene discussed is UCA1; the disease is colorectal carcinoma.