Another study reported that PVT1 also promoted the specific binding of RNA-binding proteins (Lin28 and Lin28B) to let-7 by the up-regulation of Lin28 for driving carcinogenic activity of CRC; PVT1 stabilizes and post-transcriptionally regulates Lin28, which targets the Lin28/let-7 axis and promotes tumorigenesis. The gene discussed is LIN28A; the disease is colorectal carcinoma.