GAS5 and colorectal carcinoma: As the core sub-network of CRC metastasis, YAP connected multiple ncRNAs such as GAS5, miR375, and circ1662, etc. The inactivation of YAP1 is required in cell-cell contact inhibition and act as a transcriptional co-activator to mediate the biological functions of the Hippo pathway (Zhao et al., 2007).