Meanwhile, GAS5 negatively regulated the expression of YAP, and YAP could bind to the promoter region of YTHDF3 to promote the transcription of YTHDF3, in other words, YTHDF3-GAS5-YAP-YTHDF3 formed a positive feedback loop and promoted the metastasis of CRC in an m6A-dependent manner (Ni et al., 2019). Here, GAS5 is linked to colorectal carcinoma.