PTEN and neoplasm: It should be noted that lncRNA GAS5 (growth arrest-specific 5), a tumor suppressor in CRC as a ceRNA of miR-222-3p, regulates the expression of Beclin1, LC3B, and PTEN by targeting miR-222-3p/GAS5 phosphatase and PTEN signaling pathways, thereby inhibiting CRC cell migration and invasion, and promotes autophagy (Liu et al., 2019a).