MALAT1 and neoplasm: From the network diagram, we observe that the sub-network highlights another branch of miR-194-5p, which can directly target the lncRNAs-MALAT1 harboring the rs664589 G allele in the nucleus of CRC cells, thereby regulating the nuclear expression of MALAT1 and exerting a tumor suppressor effect (Ren et al., 2018a).