METTL14 and colorectal carcinoma: A recent study further showed that MeCP2 bound to METTL14 and enhanced the m6A level of KLF4, while m6A-modified KLF4 was supposed to be stabilized by IGF2BP2 to increase the expression of KLF4, thereby inhibiting the metastasis of CRC (Wang et al., 2021).