EZH2 and colorectal carcinoma: O-GlcNAcylation and EZH2-mediated H3K27me3 modification of the miR-101 promoter region further reduce the expression of miR-101, consequently, miR-101/O-GlcNAcylation/EZH2 signals form a feedback loop that inhibits metastasis and eventually inhibits the invasion of CRC cells and regulate the EMT (Jiang et al., 2019).