In addition, studies show that ZFAS1 promotes CRC by small nucleolar RNA-mediated 2′-O methylation through NOP58 recruitment and plays essential roles through the ZFAS1-NOP58-SNORD12C/78-EIF4A3/LAMC2 signaling axis (Wu et al., 2020b). The gene discussed is ZFAS1; the disease is colorectal carcinoma.